He is my best friend and I hate seeing him do this, what do i do?

C'mon, it has only been a week! What's the rush on your part? Is there some special reason why you can't wait a while to let this play out more?

Well if she's not interested now, she won't magically become interested later. Your friend's going to have to work it out for himself. You could try saying you're concerned about it, but if he refuses to hear you out - back off. He'll eventually see what you were talking about.

He's gotta figure it out for himself. Either that or she will most likely tell him she's not interested

I would just let it go dude. My friends and I go through this all the time. We usually figure it out for ourselves before we get to into the girl.