no way. there's no tv show that ever offended me because of content, it's almost impossible to offend me anyway. south park has been a beacon of greatness for the last 20 years. how many shows can run that long and still be worthy of watching? the pc principle has been funny as hell in this season when he's on.
I've disagreed with some things the show has said, but I've watched south park for years and they are kind of a free for all. They make fun of everything and I don't take any statements made too seriously. If I don't like certain jokes or episodes, I just don't watch it.
As a bisexual, black woman who is an atheist and vegetarian, I'm sure they have said something that I disagree with. However, to offend, as in seriously upset me... I don't think I have ever had that experience with south park. That doesn't mean there's anything wrong with being offended by it, though, if you are. I'm just not.
No, because it's clear to anyone with a brain that it is comedy based on social commentary, and that they aren't afraid to call out ANYONE on their bullshit (because they do). It's supposed to make you THINK, and if you instead get offended, it's probably because you aren't real good at thinking...
South Park has offended almost everyone. It's just a matter of either being a little bitch and boycotting it because they offended you, or laughing at yourself for once, and accepting the fact that it happens to almost everyone and you're no more special than them. :P