South Park. They tend to focus on more important and real issues. They don't stop themselves from making fun out of everything. They laugh at everything, and that's what makes it so great, cause they're pulling up controversial and sensitive topics, and they're ripping them apart with humor, and truth, in most cases.
South Park. Because they actually put some (by that I mean a lot) of thought in to their episodes and content. Unlike Family Guy which is just situational comedy coupled with flash back jokes that are completely undelated to anything else in the episode.