Nope, but you can't wear other shoes after a while.
Your body gets adjusted to these shoes, flat soled shoes feel like wearing tissue boxes on your feet.
As for sketchers shapeups/toneups, they are knockoffs that are missing major components of the original that make it work, like the springbar.
Also, shapeups/toneup wear out very fast. About 6 months of regular use. I'm not even talking about the sole being rubbed out, but the fabric coming apart and hole starting to form. Nikes at least last ~2 years.
If you want real results try Masai Barefoot Technology, they are the original company in Switzerland making the shoes. They cost almost 3 times as much as the cheapo sketchers. $200-300 range. Those work.
I know, I've owned 2 sketchers pair in the last year or so and just bought the MBT ones.