What would cause a girl to all of the sudden cold shoulder a guy?

Anonymous
I have a friend who we became good friends (I did have a crush on her originally but I abandoned prospect of dating her)

After Spring break and a week of not seeing or talking to each other she came back and became much more stand offish and wouldn't talk to me nearly as much and sometimes not at all. When I confronted her about it the response I got was "I don't know what to say...I'm moody and I'm busy...if you are not comfortable you don't have to hang around me"

Didn't say it but I was hurt so for now I'm just giving myself space but I don't understand what could cause a sudden shift in behavior?
What would cause a girl to all of the sudden cold shoulder a guy?
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