Im going to be honest, the mole thing might be a problem in meeting girls. Like, some girls might make fun of him, or laugh behind his back. He will have to expect that when he goes out.
But there are a lot of things he can do about it, and meet girls easily.
First of all, he will have to embrace the mole thing. Meaning, he will have to accept it, and any criticism he might get from people. If he can do that then he can go out there and show the ladies what hes got.
What character does he have that makes people/you like him, as a person?
Is he funny? Smart? Nice? Outgoing? Good dancer maybe?
He has to show people something about him that will make them look beyond the mole.
He has to be confident, and comfortable about himself. If he is too conscious about the mole, people will notice.
If he is a funny guy, then even better. He will easily get the attention of women.
And maybe after hes truly accepted his own flaw then he can even joke about it. People will laugh with him, and think hes really kewl, and just want to hang around him.
As long as he can accept his own flaw, then he will be just fine.