Just for curiosity... i smoke weed sometimes, and i tried cocaine once
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Nothing, no cigarettes, no pot, no coke, etc.
The ONE thing I did, ONE time, were these Hawaiian Baby Woodrose seeds. They have LSA which is a milder "relative" of LSD, so it's a psychedelic.
Regular users typically take 5-8 seeds at a time from what I researched, depending how much the seeds affect them. My friend and I (given the seeds by our other friend who had taken them that morning) took 2 each, and I don't think that was enough for me.
We took them at school, at the beginning of yearbook class, which was a mildly stupid idea, but it made it way more fun.
I definitely remember having the giggles and feeling "euphoric", which for me meant wanting to greet everyone in the hallway, and wanting to touch people in yearbook (shake their hand, hug them, etc.) I could tell two of the guys in our row of seats thought we were high on weed (cause that's pretty common at my old high school).
I thought it was great and fun. My friend was lighter than me though, and he got the "extreme paranoia" effect. He wanted us to just sit still and do nothing so nobody would be suspicious. I kept laughing at his paranoia which probably made him feel even more paranoid.
Anyway... I don't regret doing them. And I'd probably do them again, with friends.1