"Always trust your first gut instincts. If you genuinely feel in your heart and soul that something is wrong, it usually is"
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It means trust your intuition. Your brain, subconsciously and unconsciously, can be telling you that something is wrong, but at a conscious level, you are not aware at yet. For example, you can think your partner is cheating on you, but you don't rationally or consciously know the reasons as to why you think that.1