How would you hint to someone you aren't interested?

Let's say someone had a MAJOR thing for you. What would be your way of subtly letting them know you are never going to date them in their life?
Updates:
+1 y
I wasn't really being specific about a situation in my life. I was more curious about how guys will hint to girls they aren't that interested.
How would you hint to someone you aren't interested?
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