When do you know it's time to give up on someone?

When you're in an on-again off-again relationship with someone you love more than anything in the world but each time you're back together they seem to pull away from you and send mixed messages (one night saying I love you, you can spend the night if you want, the next minute not talking for four days straight and making you feel like everything's falling apart once again), how do you know if you should be persistent and keep fighting for the only one you love, or give up once and for all?
When do you know it's time to give up on someone?
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