Is it rude to ask "What's wrong with you"?

el_Te_de_la_Rosa
If you notice someone doesn't look well, how to ask it politely?

Do you prefer only "What's wrong?" or What's wrong with you is fine?
Updates:
1 mo
Believe ot or not, this sentence was taught on the local cable TV. I just found a new channel last night.

From most comments, something like "Are you okay?" seems simpler and much better to ask. I was asked "What's wrong with you?" once. Then I was in silence, asking myself what's wrong with me? Lol 😅. I don't really know what to reply back because I will be analyzing the asker's intention. The good thing is I learn to say this to other people to be safe.

Thank you very much everyone.
1 mo
*Oops. I learn to beware and betrer NOT to say. Haha
Is it rude to ask "What's wrong with you"?
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