What do do about depression when NOTHING works?

Anonymous
I’ve tried therapy for 2 years, and different therapists before that for 10 years plus.
Meds made me worse and I’m clinically depressed.
Don’t know what to do at this stage after 20 years of Clinical depression, and feel only one other person in my life gets it ( a fellow clinical depressive, who also feels at a loss in terms of no options). I have no family or anyone else that can help , before that is suggested.
What do do about depression when NOTHING works?
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