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Can any amount physical brain damage change who you are?

Don-_-Don
My brother is currently in critical condition as a result of a car accident, and upon most of the problems, I've been informed he has brain damage, but to what extent I do not know. When we wakes up I'll have to go see him at some point. Should I expect him to be the same exact Jvonta (that's his name) that I've always known?
Can any amount physical brain damage change who you are?
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