What is a loser? What exactly qualifies as a loser?

People call other people losers all the time. I am not entirely sure what the exact conditions are for someone to be called a loser.

So, what is a loser?
Updates:
+1 y
Why don't we have any female answers on this yet? :O
+1 y
Still no female answers at all on this question. What the hell...
What is a loser? What exactly qualifies as a loser?
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