I usually like to watch movies with actors (even if it's just 1 or 2) I am familiar with it just makes the movie more enjoyable for me. An all good cast is usually the best and I'll be more inclined to watch it. However I'm not saying I won't watch a movie if there are no actors I'm familiar with. Is it same for you guys?
Often, knowing the actors well means that you know what roles they often play and you expect certain things characterizations from them. That can hurt your impression of how they play this part. Also, recognizing popular actors can give away certain parts of the story before they are ready to be revealed, such as who the bad guy is.