Of course. I used to weigh 340 lbs and I was ignored by almost every girl and was at most the fat funny guy friend. I look a little different now, and my life could not be better. When I visit home people don't recognize me, but I remember them and could not be less interested in them. If someone couldn't even get to know you at your worst then you shouldn't give them the time of day in my opinion.
And I would SO much rather date a girl that used to be ugly, you have a broader perspective of what things are like for other people and generally that makes you a better person.