Most Helpful Guy
This is almost always because the NRE wears off. NRE is the term for the new relationship energy at the start of a relationship. It is a chemical bath in the brain that makes the two people artificially close to each other. It is designed to bring people together so that real, long term emotions can grow in the background, as real love takes years to grow. And while it is in effect, the people have a huge amount of feelings of togetherness, that they are perfect together, that they want to be together forever. All of that. But it is just the short term chemicals making them feel that way. It can last a few weeks, a few months, often up to 2 years, and very rarely drags on for closer to 4.
If that NRE phase wears off, and other emotions haven't built in the background, the two people will start to drift, badly. That is usually where you see people break up after they have been deliriously happy together for two solid years, and suddenly... nope, no good.
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Most Helpful Girl
Cheating or lack of interest.