How long do you try to work things out before calling it quits?

A relationship of over 10 years. Mortgage and young children are involved. The relationship has been rocky for almost a year now, but it's not improving all that much. How long is too long to try? When do you know it's time?
Updates:
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Thanks for the feedback everyone. We had a big blow out the day that I posted this and I decided I've had enough. My stuff is packed along with the kids. I'm moving back home to stay with my parents for a while. It's scary. I'll now be a single parent and will need to start living and planning accordingly, but I feel like I was dying a slow and painful death with him. He was sucking the life out of me. I need a break.
How long do you try to work things out before calling it quits?
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