Most Helpful Girl
Steve Urkel and Laura Winslow are definitely the funniest couple :P
Most Helpful Guy
Peter and Lois Griffin, really unrealistic and ridiculous, but Urkel and Laura are also hilarious :P
Lewis and Betty, I mean... cheerleader and a nerd, LoL, not very likely :P
But all of these couples are quite unlikely :)
A, E, and F :)
beauty and the beast
Of those I will probably go A - Those two never looked right to me but mismatched couples are often the base of most comedies - Even leaving out romance think of a lot of mismatched leading pairs "The Odd Couple" , Charlie/Alan in "Two and A Half Men" etc.
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