I already know the answer, in my mind at least, just wanted to hear some other views. I'll add some names of Comics I think are great at it but I don't consider to be the Top most comic.
Most Helpful Girl
I'm going to say Eddie izzard, but I'm also biased because out of all I've actually met him in person (he came through my work one day) and he's a really cool guy.1
Most Helpful Guy
George Carlin. Nobody beats the guy.