Most Helpful Girl
Ouran High School Host Club
One Punch Man
Is It Wrong To Pick Up Chicks in a Dungeon?
My Love Story1
Most Helpful Guy
One Punch Man, I don't read manga myself, but I heard that one was good.2
I do though most haven't been serious comedies. The ones I'm reading right now are Noragami, Horimiya , and Domestic na Kanojo. They all have funny moments. Though I think Horimiya has more funny moments.
1.) Ouran High School Host Club, Vol. 1
2.) Yotsuba&!, Vol. 01
3.) One Piece