Girls, What advice can I give to my sister about dealing with "handsy" guys?

Anonymous
My older sister was taking the Metro on her way home last night and she said there was this scary guy (my sister's very small and said this guy was like a foot taller than her) who started asking her questions like, "where are you going" and "what's your name" and stuff. He was standing close and she was took scared to take a step. She said he grabbed her skirt and started touching her leg.
Luckily the next stop was there and even though it wasn't her stop she left and ran... She came home really distressed and asked if I knew how to deal with those kind of scenarios but I've never been in one? What would you have done?
Girls, What advice can I give to my sister about dealing with "handsy" guys?
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