When European countries colonised other places did they care about the natives at all?

Anonymous
When the British, Spanish, Dutch etc colonised back in the day did they have any rules about dealing with the natives or was it just to try and see what they can get out of it?

From whst I gather the English were better than the Spanish but i guess they were all bad? And do you think they knew there were people out there?
When European countries colonised other places did they care about the natives at all?
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