My girlfriend has two nieces. One is a bit overweight, but not too much, the other is extremely thin. I never really check them out, but I noticed that the skinny one has a lot smaller boobs, and I'm pretty sure they were bigger when she was heavier. So, are boob sizes mostly static or can changes in weight alter them to where they got smaller as she lost weight.
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What Girls Said
100% change with weight as breasts contain a lot of fatty tissue. Unless fake implants most girls with big big breasts are not thin. And women that are very thin usually have genes that don't store fat easily and that includes on their breasts so they are kinda A or B cup sizes.
Also I know from my own weight gain and losses my size changes. When I once lost a large amount of weight it was losing my cups that was the worse thing.
While weight is a major influence, it is not the only one; there is also genetics, hormones, and even aging that play a role in breast size.
For most women, yes, but there is a minority of women who have big boobs when thin or small boobs when overweight