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Does everyone get depressed?
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I believe based on a video ad I saw that the mind and life itself compensates when there is a surplus of happiness by giving you a dose of pain equal to your joy. Not all joys relapse into sorrow, but many superficial emotions do. I also believe lasting happiness is earned and many do not do the work to be happy and expect happiness to fall into their lap and then they get disappointed when they end up working to make other people happy instead of working to make themselves happy. An example I can think of is people who did not pay attention or carefully search for a wife and choose the easiest and more available options, and then end up with an abuser who wants to be served but never gives anything in return.
The main thing I believe is the circumstances they live in. Maybe their job or social life or an event that just knocks the person off their normal mojo. One of those things and I believe medicine can help but it's the person that bounces back to normal
It can lead to many stuff, lose of someone they loved, being in hard financial depth, not satisfied whit current job but knows they can't get other type of jobs, it can really be a 100 of reasons.