Which could be better? Stay in Phuket/Krabi and visit Ayuthaya/Bangkok for 3 days, or stay in Ayuthaya and visit Krabi for 3 days?

Staying in southern Thailand, I could also visit Khao Sok and possibly Malaysia.

Which area has less ladyboys? That's also something that needs to be factored in

Stay in Ayuthaya and side trip to Krabi
Stay in Southern Thailand and side trip to Ayuthaya/Bangkok
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Which could be better? Stay in Phuket/Krabi and visit Ayuthaya/Bangkok for 3 days, or stay in Ayuthaya and visit Krabi for 3 days?
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