I'd say... a full blown out dead serious slash by Dracule Mihawk would give kaido a super long good night sleep and weaken him by 70% when he recovers from that attack and gets up again.
I am not even exaggerating here... in his entire journey as the best swordsman in the world... he hasn't ever been dead serious. All of his attacks were at a normal strength level and he was capable off slashing gigantic ice mountains at marineford. Jozu nearly slipped when he tried to fend off his attack.
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