How to flirt with girls who are studious?

And are basically just at school to study? There's a girl that I'm starting to like in my med school, but the problem is that she has the mindset that she's just there to study, boys come later, so she gathered around three other girls with the same mindset and just hangs out with them during class or lab, so I'm not sure what I can do. I tried smiling at her a couple times, and one time she smiled back, but the others she either looked away before she could see me smile or just ignored it.
How to flirt with girls who are studious?
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