Men is being called Mister offensive, women is being called missy offensive?

This question is aimed more towards younger men and women like around my age but if you are past your 20s does being called this make you feel old? πŸ€”

Im asking this cause I use it a lot thats why and I don't know if I'm offending anyone tho πŸ˜‚
Men is being called Mister offensive, women is being called missy offensive?
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