Opinions please! What would you do?

How can you tell if someone is still interested. Especially lets say after having multiple intimate moments together? I know life gets hectic and sometimes it can be hard to reply but I feel like it's deliberately this guy isn't responding at times and I just don't want to be in another casual relationship, is it worth talking to him about, like if he is interested or wants anything more? No other gals are in the picture as far as I know, but I'm getting overly anxious for my own reasons with other things in life, too. He tells me to relax and then decides not to respond for 2 days, and I'm just confused. I know some people have experienced something like this, and please, I just want to know how you handled it and / or what you would do in this sort of situation, or what would you say, you know?
Opinions please! What would you do?
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