Have you ever had a bad reaction mixing medications? if so how long did the symptoms last?

I took Dramamine this morning for nausea and then NyQuil for sleep but after waking up I immediately vomited and have been feeling nervous and hot and shaky. It’s been 12 hours but still kinda feeling it. I heard about these things lasting for multiple days.
Have you ever had a bad reaction mixing medications? if so how long did the symptoms last?
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