Is it realistically possible a grown man in great physical shape and strength can beat up (no weapon) and kill a female lioness one on one in a fight?

Female lioness can weight between 270 lbs and 400 lbs. Choose the low end weight in the fight to make it fair as possible with the man weighting the same weight or more.
Is it realistically possible a grown man in great physical shape and strength can beat up (no weapon) and kill a female lioness one on one in a fight?
Is it realistically possible a grown man in great physical shape and strength can beat up (no weapon) and kill a female lioness one on one in a fight?
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