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I think the people that say "I'm 20 and don't care what people think" are the same kinds of people that low key do care and will respond to comments trying to justify what they said if someone disagrees because they care enough to do so.
From my experience, the comment above holds true. Chances are, you probably won't be friends with everybody. If you claim that you are, you are either incredibly naive or are lying. Either way, people who stand up for something probably have some enemies to worry about. Keep your friends close, your enemies closer.