When an acquaintance doesn't accept your Facebook friend request, does that mean they don't want to be friends with you in person?

Should I not even go out of my way to initiate conversation with them if I pass them at work, or should I still make efforts to be friends with them at work/out in public? I know it's not a good idea to confront them about the Facebook request, but does it still look just as desperate if I still try talking to them in general, or is it up to them to initiate conversation with me now?

When an acquaintance doesn't accept your Facebook friend request, does that mean they don't want to be friends with you in person?
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