How can I pull myself up from the depths of depression?

I'm at the very bottom right now. I've been on a new antidepressant the last two months, and they just doubled the dose, and I'm feeling worse.

Therapy doesn't work for me. I've tried it for years.

Some of you on here know me. I've been around a while.

Nothing gives me happiness anymore- video games, creating art, writing...
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I can't do anything about the one reason why I feel so terrible about myself: my endowment. I was born with a rare reproductive disorder. I'm so lonely.
How can I pull myself up from the depths of depression?
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