Sugar substitutes or high fructose corn syrup; which is the least evil?

When it comes to beverages (alcohol included), if one needs a variation from water and tea, this is the dilemma people are usually into.

Which do you think is the "better choice"?
Sugar substitutes
High fructose corn syrup
Select gender and age to cast your vote:
Sugar substitutes or high fructose corn syrup; which is the least evil?
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