This is coming from somebody who enjoys Simpsons, mainly the classic-era ones. But Lisa still happens to annoy me so much because she is one of the biggest social justice liberals on TV, even though I know she is just fictional. It's as if most of the show is written by her and from her POV, especially in more modern Simpsons. On top of that, she is a Mary Sue in a way, she is an "over-achiever" and is incapable of doing anything that might be wrong or stupid. I'd rather root for the under-achievers myself.
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