Would/Could the MCU Fantastic Four work with Dr Doom as the main villain?

Okay to state the obvious. No I do not think the MCU Fantastic Four should be the only time we see Dr Doom in the MCU. However his popularity has made it seem like he’s a general Marvel villain and not just a Fantastic Four villain. He’s meant to be the group’s archnemesis. And yet people treat him like he’s more than just that. Thanos is a general Marvel villain as he isn’t the archenemy of any single Marvel superhero. Although his DC version Darkseid is primarily the archenemy of the Justice League. But Doom isn’t, his popularity has only made it look that way. He was the first major threat for the Fantastic Four. First appearing in their 5th ever issue. And he needs to be treated like a Fantastic Four villain. The Joker is considered the greatest villain in all of comics being rivaled only by Darth Vader in terms of iconic villains. And he’s only the enemy of a single superhero. So could the MCU Fantastic Four work with Dr Doom or not
Would/Could the MCU Fantastic Four work with Dr Doom as the main villain?
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