Is being physically unattractive the worst hardship a girl could have in life?

If a girl was unattractive (whether fat or thin), would that be a worse hardship in her life than if she was attractive, yet had some other hardship (such as physical or mental health issues, low income, family issues, trauma, off-putting personality, etc)? Basically, the question is, is being invisible the worst hardship a girl could have.

Is being physically unattractive the worst hardship a girl could have in life?
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