What is causing "Deaths of Despair""?

The life expectancy in the US had dropped slightly for the first time in decades. Surprisingly Covid was not the cause. The biggest rise in deaths have come from middle aged white men. The deaths are usually due to suicide, alcoholism, drug overdoses or systemic diseases related to obesity. Why is this happening?

What the heck?
What the heck?
What is causing "Deaths of Despair""?
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