Do people ever wake up from their mid-life crisis and regret having become estranged from their spouse?

My brother and my sister-in-law are splitting up. My sister-in-love still loves him and wants him to be happy. I don't think he knows what he wants except to be happier. They've been together for over 10 years, they have 2 young children.

I want to support them and I don't know how best to. I wish my brother could address his unhappiness and desire for a life change without having to break up their family. I'm worried he'll end up hitting rock bottom and regretting it. Does that ever happen? Or will they both emerge happier from the split a few years down the line?

At the moment, it looks like they'd split amicably but I suspect beneath the surface there is much more going on.

How can I help them? I can't stop crying since I found out. I love them both.

Do people ever wake up from their mid-life crisis and regret having become estranged from their spouse?
Do people ever wake up from their mid-life crisis and regret having become estranged from their spouse?
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