My friend is really insecure and it its getting annoying, what should I do?

Anonymous
She has a slight anger problem and has struggled with depression and self harm and so have I which is why I try my best to be sympathetic and open minded but she is soo insecure it leads to paranoia and she always thinks someone including me is talking about her. a lot of times she can't really take a joke and she can very hypocritical, like something she would say to you is the same thing you couldn't say to her or would flip out at you. The most annoying thing she has done was post an OBV cute picture of her smiling w her butt poking out and captioned it as "ugly". Wtf ! She knew that picture wasn't ugly otherwise she wouldn't hve posted it for the public eye. (Btw she is extremely beautiful)
I try my best to stick shit out but being her friend is draining.

My friend is really insecure and it its getting annoying, what should I do?
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