How to know when your relationship has run its course?

My boyfriend and I have recently moved in together. Shortly before that, things just didn't feel right. We started having a lot of arguments and could never agree on anything. That's still true, but feels amplified now that we live together. I'm constantly anxious since my boyfriend has begun to take offense to what feels like everything, he doesn't talk to me about anything anymore (he says it's just the way he is and I need to accept it), and I tend to feel like an outsider in his life.

We've talked before about how our relationship just isn't the same as how it used to be and he's somehow convinced it'll work itself out and we'll get back to the way we were. He says he hasn't noticed a huge shift in our relationship dynamic, but I find that hard to believe. We can never compromise, we argue all the time (about stupid stuff), and I have a very hard time feeling loved or even accepted as I am.

In my mind, I'm thinking, "this is it", that this is the beginning of the end. He thinks we just need to work on things, but I'm finding it difficult to feel any hope. I haven't been in very many long-term relationships (this being only my second), so I don't know what it feels like when your relationship is no longer working and you need to move on. I'm obviously still invested in this, I know what we had at one point and how amazing it was and would love to have that back, but if it's just not right, it's not right...
How to know when your relationship has run its course?
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