How would you handle someone you're in a long term relationship with, saying that they had doubts about you?

How would you handle someone youre in a long term relationship with, saying that they had doubts about you?

My guy friend has been dating his girlfriend for nearly 2 years. I, like all my friends, thought they were super happy together because there was no indication otherwise, but he told me that she recently told him that she had doubts about continuing on in the relationship. He said when he asked her why, she couldn't really pinpoint one thing which, I mean, even hearing him tell it, I was like, what do you even do with that? How would you handle it if your long term partner said they had doubts?

How would you handle someone you're in a long term relationship with, saying that they had doubts about you?
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