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Most people are born with sex chromosomes that are XX (female) or XY (Male). But 1 out of 500 babies are born XXY, also known as Klinefelter syndrome or KS.
The primary features of KS are infertility and small, poorly functioning testicles. Usually, symptoms are subtle and subjects do not realize they are affected. Sometimes, symptoms are more evident and may include weaker muscles, greater height, poor motor coordination, less body hair, breast growth, and less interest in sex. Often, these symptoms are noticed only at puberty.
Due to a lack of understanding of the condition amongst healthcare providers, KS is grossly underdiagnosed, with most patients never receiving a diagnosis. Within this population, gender dysphoria is of a considerably higher incidence than in the general population.
Click here for famous people who were either diagnosed or suspected as being XXY